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Medicine

Pharmacokinetic Variability of Proton Pump Inhibitors

Quick fact

A single genetic difference in the CYP2C19 enzyme can make some people 'ultra-rapid metabolizers,' causing the PPI to be cleared from the body so quickly that it may not suppress acid at all.

Why this is interesting

Have you ever wondered why the same heartburn pill works for some people but not others, even at the same dose? The answer lies in the surprisingly personal journey of the drug through your body.