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Medicine

Pharmacokinetic Variability of Immunosuppressants in Transplant Recipients

Quick fact

Tacrolimus blood levels can vary more than 10-fold between patients on the same weight-based dose, primarily due to genetic differences in the CYP3A5 enzyme.

Why this is interesting

Two transplant patients receive the same dose of the same immunosuppressant—one ends up with rejection, the other with severe side effects. Why?