Medicine
Pharmacokinetic Variability of Immunosuppressants in Transplant Recipients
Quick fact
Tacrolimus blood levels can vary more than 10-fold between patients on the same weight-based dose, primarily due to genetic differences in the CYP3A5 enzyme.
Why this is interesting
Two transplant patients receive the same dose of the same immunosuppressant—one ends up with rejection, the other with severe side effects. Why?