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Biology

Pharmacokinetic Principles of Drug Absorption and First-Pass Metabolism

Quick fact

The liver's first-pass effect can remove up to 90% or more of an orally taken drug before it ever reaches the general circulation, a phenomenon known as the 'first-pass effect'.

Why this is interesting

Have you ever wondered why some pills need to be taken in much higher doses than the injection, or why a drug's effect can differ so drastically depending on whether you swallow it or receive it in your bloodstream? The secret lies in a hidden 'filter' in your liver.