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Medicine

Pharmacokinetic Monitoring of Aminoglycoside Therapy in Critically Ill Patients

Quick fact

In critically ill patients, the volume of distribution of aminoglycosides can increase up to two-fold due to capillary leak and fluid resuscitation, requiring higher initial doses to achieve therapeutic levels.

Why this is interesting

A single dose of gentamicin can save a life—or permanently damage the kidneys and ears. In the ICU, how do doctors hit that perfect balance?