Medicine
Pharmacokinetic Monitoring of Aminoglycoside Therapy in Critically Ill Patients
Quick fact
In critically ill patients, the volume of distribution of aminoglycosides can increase up to two-fold due to capillary leak and fluid resuscitation, requiring higher initial doses to achieve therapeutic levels.
Why this is interesting
A single dose of gentamicin can save a life—or permanently damage the kidneys and ears. In the ICU, how do doctors hit that perfect balance?