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Biology

Pharmacogenomics of Warfarin Dose Requirements in Diverse Ethnic Populations

Quick fact

Variants in two genes, CYP2C9 and VKORC1, can change warfarin dose requirements by more than 10-fold, and these variants occur at very different frequencies across ethnic populations, meaning a 'standard' dose can be dangerous for some groups.

Why this is interesting

Why do two people of the same weight and age need very different amounts of the same blood thinner to get the same effect? The answer lies in their genes, and those genes differ by ancestry.

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Pharmacogenomics of Warfarin Dose Requirements in Diverse Ethnic Populations

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