Medicine
Therapeutic Drug Monitoring of Aminoglycosides in Cystic Fibrosis
Quick fact
In CF patients, the volume of distribution for aminoglycosides is often larger, and clearance may be faster, meaning standard dosing can lead to subtherapeutic levels and increased risk of resistance.
Why this is interesting
Aminoglycosides are a lifeline for CF patients fighting Pseudomonas infections, but they can cause kidney and ear damage. How do doctors use them safely?