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Medicine

Pharmacokinetic Variability of Beta-Lactam Antibiotics in Septic Shock

Quick fact

In septic shock, the volume of distribution of beta-lactams can increase by up to 50% and clearance can double, making standard dosing either dangerously low or, in some cases, excessively high.

Why this is interesting

Patients with septic shock often receive the same dose of antibiotics as stable patients—but their bodies handle these drugs so differently that the standard dose may be ineffective. Why does the same antibiotic behave so unpredictably in these patients?