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Medicine

Beta-lactam therapeutic drug monitoring in critically ill septic patients

Quick fact

In critically ill septic patients, beta-lactam concentrations can be subtherapeutic in up to 50% of patients, even with standard dosing, because of profound changes in fluid balance and kidney function.

Why this is interesting

You are prescribed a standard dose of an antibiotic, but your body metabolizes it differently—so what if the drug never reaches a level high enough to kill the infection? In intensive care, this is a very real problem.