Saved on this device

Follow your curiosity

What discovery has been shared with you?

FACTREE gives you something interesting to discover every day — and something worth talking about together.

Start with one fact. Explore it, go deeper, then follow whichever branch catches your imagination.

Choose subjects for a surprise

Exploring any topic

Begin your discovery

Your next discovery is one click away.

Choose one or more subjects above, or leave Any Topic selected and let curiosity decide.

Medicine

Pharmacokinetic Changes in Hepatic Impairment and Dose Adjustment

Quick fact

In cirrhosis, the liver's drug-metabolizing capacity can be reduced by up to 75%, leading to higher drug levels and increased risk of toxicity. For example, the half-life of morphine can double, increasing sedation and respiratory depression risk.

Why this is interesting

Many medications are cleared by the liver, so what happens when the liver is damaged? The answer is that drug effects can become dangerously strong, but doctors can predict and prevent this.