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Medicine

Methotrexate Toxicity in Psoriasis: Folate Supplementation and Drug Interactions

Quick fact

Supplementing with folic acid—just 1–5 mg daily—can reduce methotrexate’s common toxicities (nausea, liver enzyme elevations, and blood count drops) by up to 80% without diminishing its effectiveness against psoriasis.

Why this is interesting

Methotrexate can be a miracle for severe psoriasis, but without careful management, it can silently damage the liver and bone marrow. Why do some patients get serious side effects while others thrive?

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