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Medicine

Comparative Effectiveness of DOACs vs. Warfarin in Atrial Fibrillation

Quick fact

In large trials, DOACs like apixaban and dabigatran reduced stroke risk by about 19–35% compared to warfarin, while also lowering the risk of major bleeding—the very complication doctors tried to avoid.

Why this is interesting

For decades, warfarin was the go-to blood thinner, but now doctors often choose newer pills called DOACs. Why did the gold standard change?