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Psychology

Psychosocial Interventions for Treatment-Resistant Depression

Quick fact

Psychosocial interventions, such as cognitive-behavioral therapy (CBT), have been shown to benefit up to 50% of patients with treatment-resistant depression when added to pharmacotherapy, even after multiple medication trials have failed.

Why this is interesting

When standard antidepressants fail, most patients still have powerful options—but they aren't pills. How do talking therapies change a brain that seems 'treatment-resistant'?