Medicine
Biological Therapy Switching for Rheumatoid Arthritis After Primary Failure
Quick fact
In rheumatoid arthritis, switching to a second biologic after primary failure—when the first biologic fails to achieve remission despite adequate dosing—can still lead to clinical improvement in many patients, even if the second drug has the same target.
Why this is interesting
You've just started a biologic drug for rheumatoid arthritis, but after six months your joints still hurt. Your doctor says it's time to switch. Why does switching work?