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Medicine

Population Pharmacokinetics of Vancomycin in Obese Critically Ill Patients

Quick fact

In obese critically ill patients, the volume of distribution of vancomycin is significantly increased, often requiring higher loading doses, but clearance can be highly variable—leading to paradoxical under- and over-dosing with standard regimens.

Why this is interesting

You might think that a heavier patient simply needs a larger dose of vancomycin, but in the ICU, obesity and critical illness twist the drug's behavior in unexpected ways. How do clinicians know the right dose?