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Medicine

Pharmacokinetic Drug Interactions with Antiepileptic Drugs

Quick fact

Phenytoin, a widely used AED, is a potent inducer of several CYP450 enzymes, which can reduce the blood levels of oral contraceptives, leading to unintended pregnancies in women taking both.

Why this is interesting

You take a common AED for seizures, and suddenly your blood pressure medication stops working—or becomes dangerously potent. Why would a seizure drug change the effect of an unrelated medicine?