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Medicine

Pharmacogenomics of Warfarin Dosing: CYP2C9 and VKORC1

Quick fact

Two genetic variants in the CYP2C9 and VKORC1 genes can explain about 30-40% of the variability in warfarin dose requirements among patients, and genetic testing can help reduce the risk of hospitalization due to bleeding.

Why this is interesting

You and your neighbour take the same medication, but you need triple the dose to get the same effect. Why? For warfarin, the answer may be written in your genes.