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Medicine

How Hepatic Uptake Transporters (OATPs) Shape Statin Drug Interactions

Quick fact

Blocking the OATP uptake transporter in the liver can double or even triple the blood levels of some statins, dramatically increasing the risk of muscle damage and kidney failure.

Why this is interesting

You've probably heard that mixing certain drugs with statins can be dangerous, but why does a transporter protein in your liver play the starring role?