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Medicine

Drug-Drug Interactions Between Direct Oral Anticoagulants and Azole Antifungals

Quick fact

Azole antifungals like ketoconazole and itraconazole can increase the plasma concentration of certain DOACs (such as rivaroxaban) by up to 2-3 times, significantly elevating the risk of major bleeding.

Why this is interesting

You might think that taking a blood thinner and an antifungal together is routine, but the combination can be a recipe for internal bleeding. How can an antifungal make a blood thinner more dangerous?

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Drug-Drug Interactions Between Direct Oral Anticoagulants and Azole Antifungals

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