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Medicine

Genomic Markers of Drug-Induced Liver Injury Susceptibility

Quick fact

Specific variants of the HLA class I and class II genes are strongly associated with DILI from common drugs; for example, HLA-B57:01 is linked to a 7-fold increased risk of flucloxacillin-induced liver injury, yet this variant is present in fewer than 5% of the population.

Why this is interesting

Every year, seemingly safe drugs—like antibiotics or painkillers—cause severe liver failure in a few patients. Why does one person's liver tolerate a drug while another's fails catastrophically?

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Genomic Markers of Drug-Induced Liver Injury Susceptibility

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