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Medicine

Microbiome Modulation Therapy for Recurrent Clostridium difficile Infection

Quick fact

Fecal microbiota transplantation (FMT) has a success rate of around 80-90% for recurrent C. difficile infection, while antibiotics alone have a less than 50% success rate; in 2022-2023, the FDA approved the first two microbiome-based therapies for this indication, marking a break from the antibiotic paradigm.

Why this is interesting

Antibiotics are supposed to cure infections, but in some cases they can create a vicious cycle of gut infection that returns again and again. What if the solution isn't another drug, but restoring the ecosystem that was damaged in the first place?