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Medicine

Osteoarthritis Pathophysiology and the Role of Subchondral Bone Remodeling

Quick fact

In osteoarthritis, the subchondral bone remodels abnormally, becoming thicker and stiffer, which accelerates cartilage loss—not the other way around.

Why this is interesting

You might think osteoarthritis is just cartilage wearing away with age—but what if the bone below it is secretly calling the shots?