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Chemistry

How Chirality Affects Drug Efficacy and Safety

Quick fact

The drug thalidomide, prescribed for morning sickness in the 1950s, had two mirror-image forms: one treated nausea, the other caused severe birth defects. This tragedy is a stark lesson in chirality.

Why this is interesting

You take a painkiller expecting relief, but your body might only respond to half the molecules — the other half could be useless or even dangerous. Why would identical chemical formulas behave so differently?

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How Chirality Affects Drug Efficacy and Safety

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