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Chemistry

How Molecular Docking Predicts Ligand-Binding Affinity at Receptor Sites

Quick fact

Molecular docking can virtually screen thousands of candidate drug molecules against a protein target in a single day, long before any chemical is synthesized or tested in a lab.

Why this is interesting

You've probably seen a key fitting into a lock, but what if both the key and the lock are shaped by thousands of weak molecular forces? How do scientists predict which drug will bind best—without touching a single test tube?