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Biology

How DNA Base Pairing Drives Hybridization Assays in Molecular Diagnostics

Quick fact

Hybridization is so specific that even a single nucleotide mismatch can prevent binding, which is how tests can pinpoint one mutation among three billion base pairs.

Why this is interesting

You’ve likely had a DNA test, but have you ever wondered how a machine can tell a virus from your own genes in minutes? The secret lies in a simple rule of molecular attraction.