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Biology

Role of mechanotransduction in cardiac hypertrophy and remodeling

Quick fact

The heart's ability to sense mechanical stretch is so sensitive that a single extra millimeter of stretch on a cardiac muscle cell can activate signaling pathways that trigger changes in gene expression within minutes, leading to hypertrophy.

Why this is interesting

Your heart beats about 100,000 times a day, and every beat creates physical forces on its cells. How does your heart 'feel' these forces and decide to grow stronger—or dangerously thicker?