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Medicine

Acute Kidney Injury in Rhabdomyolysis: Pathophysiology and Treatment

Quick fact

In rhabdomyolysis, myoglobin entering the bloodstream can precipitate in kidney tubules and cause acute tubular necrosis; aggressive IV fluids can raise urine output to flush the myoglobin out, reducing the risk of permanent kidney damage.

Why this is interesting

Crushed muscle may not kill you directly—but the chemicals it releases into your blood can shut down your kidneys. How does a leg injury become a kidney emergency?