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Medicine

Endothelial Glycocalyx Degradation in Sepsis and Therapeutic Targeting

Quick fact

Within just 30 minutes of sepsis onset, up to 60% of the endothelial glycocalyx can be shed, releasing its components (like syndecan-1) into the blood, which are now used as biomarkers of severity.

Why this is interesting

Your blood vessels are lined with a microscopic, sugar-coated 'fuzz' that keeps fluid inside—but during sepsis, this protective layer is stripped away within hours. Why does this happen, and can we stop it?