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Medicine

Pathogenesis of Metal Allergies from Orthopedic Implants

Quick fact

Metal allergy from orthopedic implants is a type IV hypersensitivity reaction, a delayed immune response that can take days to develop, and it is a recognized cause of implant failure, affecting up to 5% of patients with metal-on-metal implants.

Why this is interesting

You've probably heard of people allergic to nickel in jewelry, but what happens when a metal hip or knee replacement starts to cause pain and swelling? Could the implant itself be triggering an allergic reaction?

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Pathogenesis of Metal Allergies from Orthopedic Implants

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