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Chemistry

N-Carboxyanhydride Ring-Opening Polymerization of Amino Acids

Quick fact

N-Carboxyanhydrides (NCAs) were first synthesized by Hermann Leuchs in 1906, yet they remained laboratory curiosities for decades. Today, NCA ring-opening polymerization is the go-to method for synthesizing high-molecular-weight polypeptides for biomaterials and drug delivery systems.

Why this is interesting

You know proteins are built from amino acids in nature, but how do chemists build synthetic proteins in the lab? The answer lies in a cyclic molecule that springs open like a jack-in-the-box, linking amino acids into long chains.

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N-Carboxyanhydride Ring-Opening Polymerization of Amino Acids

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