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Chemistry

The Role of Thioredoxin in Cellular Redox Regulation

Quick fact

Thioredoxin is a tiny protein (about 12 kDa) that acts as a universal disulfide reductase, reducing oxidized protein thiols to restore their function. It is regenerated by thioredoxin reductase and NADPH, making it a central player in cellular redox homeostasis and antioxidant defense.

Why this is interesting

Inside every cell, a small protein acts as a molecular janitor, constantly fixing the damage caused by oxygen. But how does it know which proteins need repair, and why does its job matter for your health?

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The Role of Thioredoxin in Cellular Redox Regulation

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