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Chemistry

The Role of Nicotinamide Adenine Dinucleotide in Hydride Transfer Reactions

Quick fact

NAD+ accepts a hydride ion (a proton with two electrons) at the C4 position of its nicotinamide ring, forming NADH—a reaction central to hundreds of metabolic processes, including glycolysis and the citric acid cycle.

Why this is interesting

You've probably heard of NAD+, but did you know that this small molecule is the cell's ultimate hydride taxi? How does it pick up and deliver the hydrogen atoms that power your body?