Chemistry
The Chemistry of Beta-Lactams and Their Mechanism of Inhibiting Transpeptidases
Quick fact
Beta-lactam antibiotics work by mimicking the natural substrate of transpeptidase enzymes—the D-alanyl-D-alanine end of peptidoglycan strands—and then forming a covalent bond that permanently blocks the enzyme's active site.
Why this is interesting
You've probably taken penicillin, but have you ever wondered how a simple molecule can stop a bacterial infection? The secret lies in a strained ring that tricks a key enzyme into a fatal embrace.