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Chemistry

How pH Affects Amino Acid Charge and Protein Solubility

Quick fact

Each protein has a specific pH called its isoelectric point (pI) where its net charge is zero—and at that pH, it's often the least soluble and can precipitate out of solution.

Why this is interesting

You've probably heard that proteins need the right pH to work, but why do they sometimes clump and fall out of solution? The secret lies in their electric charge.