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Chemistry

Understanding Acid–Base Titrations in Non-Aqueous Solvents

Quick fact

In a non-aqueous solvent like glacial acetic acid, even a weak base like caffeine can be titrated accurately because acetic acid enhances its basicity—something impossible in water.

Why this is interesting

You’ve titrated acids and bases in water, but what if the substance is too weak to show a clear endpoint? The secret lies not in the titrant, but in the solvent itself.