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Biology

Neuroanatomy of Default Mode Network Disruptions in Alzheimer Disease

Quick fact

In Alzheimer's disease, amyloid plaques often accumulate earliest and most heavily in the posterior cingulate cortex and precuneus, which are core nodes of the default mode network, even before noticeable memory loss occurs.

Why this is interesting

Ever noticed that when you're daydreaming or just letting your mind wander, your brain is doing something important? Now imagine that this 'default' state is one of the first things to break in Alzheimer's disease—why would that be?

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Neuroanatomy of Default Mode Network Disruptions in Alzheimer Disease

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