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Biology

Neutrophil Extracellular Traps in Autoimmune Disease Pathogenesis

Quick fact

NETs are composed of DNA and antimicrobial proteins, and they can act as a source of self-antigens. In lupus, impaired clearance of NETs is linked to the production of anti-double-stranded DNA antibodies, a hallmark of the disease.

Why this is interesting

Your immune system's first responders—neutrophils—can cast deadly webs that, when gone wrong, may turn your own body into an enemy. How do these microscopic traps, designed to catch bacteria, become a trigger for autoimmune diseases?

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Neutrophil Extracellular Traps in Autoimmune Disease Pathogenesis

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